Danjiangkou Reservoir has a feature of wide water surface and large depth,which leads to great diffi culties in water quality management due to dispersive and diverse pollution sources. In order to support prediction and early warning of reservoir water quality,and improve decision-making in response to emergencies,based on the new generation of information technology,high-precision hydrodynamic water quality models,online water quality simulations,and three-dimensional simulation technology for water quality concentration fi eld have been developed on the basis of collecting massive monitoring data. These technologies simulate the three-dimensional movement of water and the diff usion process of pollutants in the reservoir. A water quality safety “four pre” platform is developed, including functions of monitoring and analysis,online inference,warning analysis,situation rehearsal,and emergency response management. This platform has been successfully applied to actual management work such as the changing trend of total phosphorus and pollution risk analysis in Danjiangkou Reservoir during the sudden drought-flood reversal conditions between 2021 and 2022,providing strong support for the water quality management of the middle route of the south-to-north water transfer project.