Focusing on the key scientific and technological problems of forecasting,early warning,rehearsal,andpreplan faced by the major needs of fl ood control and disaster reduction in the Huaihe River basin, new technology ofspace and earth intergration is used in this paper,such as UAV,laser radar and satellite remote sensing. This paper buildsa data base with high-precision and multi-elements based on multi-source and multi-scale information technology,and builds a large-scale coupled hydrological and hydrodynamic simulation by using hydrological and hydrodynamic numerical simulation and parallel computing techniques. Based on the high-precision data base,high-performancecomputing power and high-precision algorithm,the flood control “four pre” platform of digital twin Huaihe River isestablished,which is applied in the review of major floods in 2020 and multiple rainstorm floods from 2021 to 2022in the Huaihe River basin. The results show that the number of calculation nodes has been refined from 9 to 5 157,the size of calculation units has been refi ned from 9648 km2 to 17 km2,and the average effi ciency coeffi cient is 0.8. The relative error of predicted flow peak at main control stations in the Huaihe River mainstream is basically below 10%,and the prediction period of flood can reach 2 ~ 4 days. The detailed simulation of all elements of the whole basin can be realized,which provides technical support for the digital twin basin,flood forecasting and project dispatching.