Taking the Yongning River Basin as a pilot,this paper aims to construct a digital twin river basin and build a “2 + N ” business application system with “four pre” functions,so as to comprehensively guarantee the regional flood control safety. Considering the objective reasons such as rugged terrain,complex land use types,and multiple administrative regions in the river basin,a flood prediction model for Yongning River is established to improve the prediction accuracy based on series of the Mike models. Adopted the 2013 “Fitter”,2015 “Surodi” and 2019 “Lekima” floods as calculated sessions,based on five flood rates selected from the hydrological data from 2013 to 2019,the results show that the simulation of each station is basically consistent with the measured process line trend. The errors of peak water level are 1.31% at the Xialu station,2.23% below the Xijiang River Gate,-0.98% on the Yongning River Gate,and 0.04% at the Nanyang station. The average flood peak error of the four stations is 0.58%,and the average error of flood peak delay time is 0.8 hours. The deterministic coefficient of the main forecast stations is above 0.7, and the calculation time is within 30 seconds. Moreover,the forecast model,information of project scheduling and the digital twin basin system are integrated,and the industrial situation and flood control of Yongning River are displayed as a whole,so as to realize the intelligent decision-making of flood control for the Yongning River Basin and provide a powerful numerical analysis guarantee for scheduling and command.